H-InvDB x AHG DB
H-InvDB x AHG DB
H-InvDB_8.3 released on March 26, 2013.
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News

20-Apr-12  H-InvDB 8.0 (Annotated Human Gene Database) was released.
The features of this major release include:
- 249,012 human transcripts in 45,847 human gene clusters (loci).
- updates of human genome sequences to NCBI b37.1 (UCSC hg19).
- new relase of positional information in GFF3 format at Download/Results of computational analysis
- updates of subdatabases; DiseaseInfo Viewer, H-ANGEL, G-integra

README

10-Sep-10  Erratum for H-InvDB_7.5 Evola annotation
In H-InvDB_7.5 Evola, annotation for 19,561 IDs below will be revised in the comming release.
Link : erratum20100910.txt

10-Sep-10  H-InvDB 7.5 (Annotated Human Gene Database) was released.
The features of this minor release include:
- Re-difinition of human gene clusters on NCBI b37.1 (UCSC hg19) by re-filtering the predicted gene models
- 242,813 human transcripts in 44,806 human gene clusters (loci).
- Improvement on alternative splicing annotation pipeline and update of H-DBAS
- Update in human protein-protein interaction (PPI) and update of PPI view
- Updates of subdatabases; G-integra, DiseaseInfo Viewer, H-ANGEL, Gene family/groups

README

31-Mar-10  Erratum for H-InvDB_7.0 annotation
In H-InvDB_7.0, annotation for 916 IDs were revised since 16-Feb-10.
Link : erratum20100331.txt

16-Feb-10  H-InvDB 7.0 (Annotated Human Gene Database) was released.
The features of this major release include:
- 296,912 human transcripts in 46,499 human gene clusters (loci).
- updates of human genome sequences to NCBI b37.1 (UCSC hg19).
- Release of new main viewer, "Protein vew". sample
- Release of annotation of ORANGUTAN in G-integra
- Tie-up with GlycoProt DataBase (GPDB)
- Relation to experimental resources (NBRC and HGPD)
- updates of subdatabases; DiseaseInfo Viewer, H-ANGEL, Gene family/groups

README

14-Jan-10  Renewal of HEAT
H-InvDB Enrichment Analysis Tool (HEAT) was renewed. We newly included analysis of common sequence motifs in promoter regions based on the JASPAR database in addition to 8 kinds of annotation such as GO and KEGG pathway. Moreover, HEAT became more useful as it accepts more kinds of IDs and the download function was added. Please try the HEAT.

08-Apr-09  H-InvDB Enrichment Analysis Tool (HEAT), a new tool for GSEA, was released.
H-InvDB Enrichment Analysis Tool (HEAT) is a data-mining tool for automatically identifying features specific to a given human gene set. HEAT searches for H-InvDB annotations that are significantly enriched in a user-defined gene set, as compared with the entire H-InvDB representative transcripts. The following features of H-InvDB are analyzed: InterPro, Gene Ontology (GO), KEGG pathway, Chromosomal band, Gene family, SCOP (structural domains), Subcellular localization prediction (by using Wolf PSORT) and Tissue-specific gene expression (10 tissue categories defined in H-ANGEL). This technique is called Gene Set Enrichment Analysis (GSEA), and is popularly used in analyzing results of microarray experiments.
URL: http://hinv.jp/HEAT/

30-Mar-09  H-InvDB 6.2 (Annotated Human Gene Database) was released.
The features of this minor release include:
- 219,765 human transcripts in 43,161 human gene clusters (loci).
- "Topic annotation for NEDO FL-cDNA Annotation PJ" page newly open.
- G-integra "Comparative mapping track" newly open.
- Evola "Cross-species mapping (CSM) view" newly open.
- tie-up with GlycoGene DataBase (GGDB)
- Annotation data for the molecular evolution (Evola), disease relation (DiseaseInfo Viewer), gene expression (H-ANGEL) and polymorphism were released.
- updates of IDs of the external databases (HUGO, EntrezGene).
- "Statistics"page newly open.

README

04-Feb-09  Erratum for H-InvDB_6.0 annotation
In H-InvDB_6.0, annotation for 194 IDs were revised since 18-Dec-08.
Link : erratum20090204.txt

18-Dec-08  H-InvDB 6.0 (Annotated Human Gene Database) was released.
The features of this major release include:
- updates of human genome sequences to NCBI B36.2.
- 219,765 human transcripts in 43,161 human gene clusters (loci).
- "Topic annotation" page newly open.
- tie-up with the functional RNA database (fRNAdb)
- extended web service (REST and SOAP)
- RSS service started
- Japanese official site opened

README

04-Dec-08  Presentations related to H-InvDB at BMB2008
The 31st Annual Meeting of the Molecular Biology Society of JAPAN, The 81st Annual Meeting of the Japanese Biochemical Society (BMB2007)
9th- 12th December, 2008 at Kobe Port Island, Hyogo, Japan
http://www.aeplan.co.jp/bmb2008/en/


30-Oct-08  Release of a new portal site (medals.jp)
Opened a new portal site that provides various information on databases and analysis tools for life science which were developed by the projects directly sponsored by METI, or developed by the Institutes sponsored by METI.
The name of the site, "MEDALS", stands for METI Database portal for Life Science.
http://medals.jp


22-Oct-08  BIRC server will temporarily stop
The H-InvDB at the BIRC site will be unavailable due to electrical maintenance during the following period.
Please use the DDBJ mirror site (http://hinvdb.ddbj.nig.ac.jp/).
November 28 (Friday) 16:00 - November 29 (Saturday) 24:00 JST.

22-Oct-08  DDBJ server will temporarily stop
The H-InvDB at the DDBJ site will be unavailable due to electrical maintenance during the following period.
Please use the BIRC site (http://h-invitational.jp/hinv/ahg-db/).
October 30 (Friday) 17:00 - November 4 (Tuesday) 12:00 JST.

30-Sep-08  H-InvDB 5.3 (Annotated Human Gene Database) was released.
The features of this minor release include:
- updates of evolutionary annotation at Transcript view, G-integra and Evola.
__ URL : http://h-invitational.jp/evola/
- updates of search index for the copy number variation (CNV).
- updates of IDs of the external databases (HUGO, EntrezGene, InterPro, GO).
- release of Gbrowse of VarySysDB.
__ URL : http://h-invitational.jp/varygene/

30-Sep-08  H-InvDB demo at BioJapan2008.
BioJapan2008, World Bisiness Forum
15-17 October 2008, Pacifico Yokohama, Yokohama, Japan
http://expo.nikkeibp.co.jp/biojapan/eng/index.html


30-Apr-08  BIRC server will temporarily stop
The H-InvDB at the BIRC site will be unavailable due to system maintenance during the following period. August 19 (Tuesdat) 04:30 - 06:30 JST. (1h) Please use the DDBJ mirror site (http://hinvdb.ddbj.nig.ac.jp/).

30-Apr-08  Erratum for H-InvDB_5.0 Evola annotation
In H-InvDB_5.0 Evola, annotation for 1,149 IDs below will be revised in the comming release.
list of IDs

28-Mar-08  New URL of H-InvDB
The URL of H-InvDB was changed since 7 March, 2008 as below;
-current URL
http://jbirc.jbic.or.jp/hinv/
-new URL
http://h-invitational.jp/hinv/

Please update your bookmarks and links !

30-Jan-08  Erratum for H-InvDB_5.0 annotation
In H-InvDB_5.0, annotation for 35,120 IDs were revised since 2007-Dec-26.
Link : erratum20080130.txt

30-Jan-08  New Advanced Search (pre!) was released.
"new Advanced Search (pre!)" was released. The new search system can be accessed from Navi.

26-Dec-07  H-InvDB 5.0 (Annotated Human Gene Database) was released.
The features of this major release include:
- updates of human genome sequences to NCBI B36.2.
- Total amounts of 187,156 human transcripts in 36,073 human gene clusters (loci), with 124,280 proteins annotations(HIPs)
- New IDs of H-Invitational gene family/group IDs (HIF ID)
- predicted genes (eHIT, pHIT)
- Extended annotations for:
    * Gene family/Group
    * protein-protein interactions (PPI)
    * functional RNA
    * sequence quality
- Web service (REST protocol)
- the additional species data in G-integra and Evola (14 species including 2 species added).

22-Nov-07  JBIRC server will temporarily stop
The H-InvDB at the JBIRC site will be unavailable due to electrical maintenance during the following period. Please use the DDBJ mirror site (http://hinvdb.ddbj.nig.ac.jp/).
November 30 (Friday) 16:00 - December 1 (Saturday) 24:00 JST.

27-Sep-07  H-InvDB 4.6 (Annotated Human Gene Database) was released.
The features of this minor release include:
- Microarray probes of DNA Chip Research AceGene, Affymetrix GeneChip, and Agilent.
(from DNAProbeLocator: http://www.jbirc.jbic.or.jp/DNAProbeLocator/ )
- H-InvDB glossary (Both English and Japanese).
http://jbirc.jbic.or.jp/hinv/help/help_Glossary.html
- revisions at SNP annotation.
- updates of RASV (Representative Alternative Splicing Variant) functional annotation.
- updates of IDs of the external databases (HUGO, EntrezGene).

1-Aug-07  Erratum for polymorphism annotation
In H-InvDB_4.3, polymorphism annotation for 20,263 transcriptsare incorrect since 27-Jun-2007.
Link : erratum20070801.txt
VaryGene : http://www.jbirc.jbic.or.jp/varygene/

27-Jun-07  H-InvDB 4.3 (Annotated Human Gene Database) was released.
The features of this minor release include:
- updates of (ncRNA, SNP) annotation.
- modification of annotations about mitochondrial genes.
- updates of IDs of the external databases (HUGO, EntrezGene, InterPro, GO).
- the Japanese page of gene family annotation.
__ URL : http://h-invitational.jp/hinv/genefamily/index_en.cgi
- updates of Evola (Evolutionary annotation database).
__ URL : http://jbirc.jbic.or.jp/hinv/evola/
- release of VaryGene, new database for polymorphism information.
__ URL : http://www.jbirc.jbic.or.jp/varygene/

8-Jun-07  Approval of Evola at the HUMOT project
- Human and Mouse Orthologous Gene Nomenclature project -
http://www.genenames.org/activities/humot/index.html

The HUMOT (Human and Mouse Orthologous Gene Nomenclature) project aims to approve the equivalent gene symbol for each human/mouse ortholog pair, supported by HGNC and MGI.
Evola, a database of evolutionary annotation in H-InvDB,
http://jbirc.jbic.or.jp/hinv/evola/
is now approved as one of the resources of the human/mouse ortholog annotation at the HUMOT project.

11-May-07  The poster presentations of H-InvDB will be presented at HGM2007.
HUGO's 12th Human Genome Meeting (HGM2007)
21-24 May 2007, Montreal Convention Center, Montreal Canada.
http://hgm2007.hugo-international.org/

"Extended annotation for the integrated database of human transcriptome, H-InvDB" Yamasaki C. et al.
"H-DBAS: Alternative Splicing Database of Completely Sequenced and Manually Annotated Full-length cDNAs Based on H-Invitational" Takeda J. et al.

25-Apr-07  The network maintenance at JBIRC server
The H-InvDB at JBIRC site is temporalily unavailable, due to a network maintenance.
April 26 (Thursday) 02:00 - April 26 (Thursday) 04:00 JST.

30-Mar-07  H-InvDB 4.0 (Annotated Human Gene Database) was released on March 30, 2007.
The features of this major release include:
- updates of human genome sequences to NCBI B36.1.
- the new dataset of 175,542 human transcripts in 34,701 human gene clusters (loci).
- annotation of the four selected gene families (TCR, Ig, MHC, Olfactory receptors)
- predicted genes from genome sequences (G-integra)
- Advanced/Navi search
- Transcript view/Locus view
- the additional species data in G-integra and Evola (12 species including 8 species added).

24-Jan-07  The mirror site (DDBJ) will temporarily stop
The H-InvDB mirror at the DDBJ will be unavailable due to maintenance during the following period.
January 26 (Friday) 17:00 - January 28 (Sunday) 13:00 JST.
Services unavailable are:
* mirror site
http://hinvdb.ddbj.nig.ac.jp/ahg-db/index.jsp
* H-Invitational Database CIB-DDBJ Flat File server
http://hinv.ddbj.nig.ac.jp/ (English)
http://hinv.ddbj.nig.ac.jp/index-j.html (Japanese)

20-Dec-06  H-InvDB 3.8 (Annotated Human Gene Database) was released on December 20, 2006.
The features of this minor release include:
- PPI view (protein-protein interaction data).
- updates of IDs of the external databases (HUGO/Entrez Gene).
- updates of?iSNP, ncRNA, AS).
- the Japanese pages of BLAST server and help desk.
- H-DBAS (Alternative Splicing database).

5-Dec-06  The mirror site (DDBJ) will temporarily stop
The H-InvDB mirror at the DDBJ will be unavailable due to maintenance during the following period.
December 9 (Saturday) 8:00 - December 9 (Saturday) 18:00 JST.
Services unavailable are:
* mirror site
http://hinvdb.ddbj.nig.ac.jp/ahg-db/index.jsp
* H-Invitational Database CIB-DDBJ Flat File server
http://hinv.ddbj.nig.ac.jp/ (English)
http://hinv.ddbj.nig.ac.jp/index-j.html (Japanese)

30-Nov-06  The poster presentations/demonstration of H-InvDB in MBSJ2006 Forum
There will be some poster presentations/demonstration of H-InvDB in MBSJ2006 Forum (Nagoya Congress Center), Nagoya, Japan. [December 6 th (Wednesday) - 8 th (Friday), 2006]
See details.
http://jbirc.jbic.or.jp/hinv/ahg-db/presentation.jsp
MBSJ 2006 Forum
http://www.aeplan.co.jp/mbsj2006forum/

6-Nov-06  JBIC server will temporarily stop
The H-InvDB at the JBIC site will be unavailable due to electrical maintenance during the following period. Please use the DDBJ mirror site (http://hinvdb.ddbj.nig.ac.jp/).
November 24 (Friday) 15:00 - November 25 (Saturday) 24:00 JST.

6-Nov-06  The mirror site (DDBJ) will temporarily stop
The H-InvDB mirror at the DDBJ (see below in detail) will be unavailable due to maintenance during the following period.
November 10 (Friday) 17:00 - November 13 (Monday) 10:00 JST.
Services unavailable are:
* mirror site
http://hinvdb.ddbj.nig.ac.jp/ahg-db/index.jsp
* H-Invitational Database CIB-DDBJ Flat File server
http://hinv.ddbj.nig.ac.jp/ (English)
http://hinv.ddbj.nig.ac.jp/index-j.html (Japanese)

28-Sep-06  H-InvDB 3.6 (Annotated Human Gene Database) was released on September 28, 2006.
The features of this minor release include:
- updates of IDs of the external databases (HUGO/Entrez Gene).
- updates of Evola (Evolutionary annotation database).
- the Japanese page of the site map, download site.
- H-InvDB mail magazine.
- subscription and registration page for the mail magazine.

1-Aug-06  H-InvDB mail magazine founded.
H-InvDB mail magazine first released on August 1, 2006.
To subscribe or see back numers, check http://jbirc.jbic.or.jp/hinv/mag/ .

1-Jul-06  Release of new tool: TACT; Transcriptome Auto-annotation Conducting Tool
We developed and released a new web-tool, TACT (TranscriptomeAuto-annotation Conducting Tool ). TACT conduct functional annotation of transcripts by the integration of sequence similarity searches and functional motif predictions. [Nucl. Acids Res. 2006 34]
http://www.jbirc.jbic.or.jp/tact/

23-Jun-06  H-InvDB 3.4 (Annotated Human Gene Database) was released on June 23, 2006.
The features of this minor release include:
- updates of non-protein-coding RNA annotation.
- updates of transcribed pseudogene annotation.
- updates of IDs of the external databases (HUGO/Entrez Gene).
- the Japansese version of help pages.

31-Mar-06  H-InvDB 3.0 (Annotated Human Gene Database) was released on March 31, 2006.
The features of this major release include:
- expansion of the dataset to 167,992 human transcripts in 35,005 human gene clusters (loci).
- updates of all the annotation based on data fixed on March 1, 2005.
- updates of human genome to NCBI B35.1.
- search navigation (wizard).
- site map
- renewal of top/help pages (The top pages have the Japanese language version)
(Note: To change the language configuration, See [ help ])

31-Mar-06  The poster presentations of H-InvDB will be presented at HGM2006.
HUGO's 11th Human Genome Meeting, HGM2006.
[May 31 (Wednesday) to June 3 (Saturday), 2006 at Helsinki, Finland]
http://hgm2006.hugo-international.org/
"Recent Advancement of H-Invitational Database, An Integrated Database of the Human Transcriptome"
Tadashi Imanishi*, Chisato Yamasaki, Katsuhiko Murakami, Yasuyuki Fujii, Yoshiharu Sato, Motohiko Tanino, Ryuichi Sakate, Takayuki Taniya, Yumi Yamaguchi-Kabata and Takashi Gojobori
"TACT: Transcriptome Auto-annotation Conducting Tool of H-InvDB"
Chisato Yamasaki*, Hiroaki Kawashima, Fusano Todokoro, Yasuhiro Imamizu, Makoto Ogawa, Motohiko Tanino, Takeshi Itoh, Takashi Gojobori and Tadashi Imanishi

27-Jan-06  H-InvDB 2.4 was released on January 27, 2006.
The new features include:
- updates of IDs of the external databases (HUGO/Entrez Gene).
- alternative splicing isoforms (pattern classification).

11-Jan-06  Mirror site stop
The H-InvDB mirror at the DDBJ site will not be available due to temporary work during the following period.
January 13 (Friday) 9:00 - January 13 (Friday) 13:00 (JST).

30-Nov-05  H-InvDB was updated on November 30, 2005.
The new features include:
- updates of IDs of the external databases (HUGO/Entrez Gene).
- updates of annotations of SNPs
- a table with the contents of the gene expression profile database (H-ANGEL) is added in the download page.

21-Nov-05  Mirror site stop
The H-InvDB mirror at the DDBJ site will not be available due to electrical maintenance during the following period.
December 2 (Friday) 17:00 - December 3 (Saturday) 22:00.
29-Jul-13  Erratum for H-InvDB_8.3
- Errors in PPI data were fixed.
- Missing information about data release/update date was recovered.
- The following donwload files were updated.

20-Apr-13  20th April, 2013, the 9th anniversary of H-InvDB !!

26-Mar-13  H-InvDB 8.3 (Annotated Human Gene Database) was released.
The features of this minor release include:
- Update in orthologue information
- Update in human protein-protein interaction (PPI) and update of PPI view
- Updates of subdatabases; H-ANGEL

21-Dec-12  Erratum for H-InvDB_8.0
- Some records missing in the former release were recovered. (Link : HIT HIX HIP)
- SNP information bugs were fixed and missing data was recovered.
- Other minor bugs were fixed.

21-Dec-12  Publication reporting recent progress in H-InvDB (NAR database issue 2013)

21-Dec-12  Release of Human Protein Complex Database with a complex quality index (PCDq)
PCDq is a human protein complex database with quality index, which tells us the evidence level as members of the protein complex. We predicted human protein complexes from integrated PPI network data by finding densely connected regions with their cluster properties in the PPI network. We annotated the predicted complexes with our defined procedures by human curators that confirm the existence of the complex actually available in references. We integrated data entities such as protein function, localization, structure, expression profile, gene locus, and binary interactions among complex member proteins and complex outside adjacent proteins.
URL: http://h-invitational.jp/hinv/pcdq/

21-Dec-12  Release of H-Inv Extended Protein Database (H-EPD)
H-Inv Extended Protein Database (H-EPD) provides comprehensive, non-redundant human protein sequences, including both curated and predicted human proteins. It was made by merging H-Inv proteins (predicted from transcriptome) with UniProtKB/Swiss-Prot and RefSeq proteins (curated). H-EPD was designed as a reference database for human proteome research.
URL: http://hinv.jp/hinv/h-epd/

20-Apr-12  H-InvDB 8.0 (Annotated Human Gene Database) was released.
The features of this major release include:
- 249,012 human transcripts in 45,847 human gene clusters (loci).
- updates of human genome sequences to NCBI b37.1 (UCSC hg19).
- new relase of positional information in GFF3 format at Download/Results of computational analysis
- updates of subdatabases; DiseaseInfo Viewer, H-ANGEL, G-integra

README

10-Sep-10  Erratum for H-InvDB_7.5 Evola annotation
In H-InvDB_7.5 Evola, annotation for 19,561 IDs below will be revised in the comming release.
Link : erratum20100910.txt

10-Sep-10  H-InvDB 7.5 (Annotated Human Gene Database) was released.
The features of this minor release include:
- Re-difinition of human gene clusters on NCBI b37.1 (UCSC hg19) by re-filtering the predicted gene models
- 242,813 human transcripts in 44,806 human gene clusters (loci).
- Improvement on alternative splicing annotation pipeline and update of H-DBAS
- Update in human protein-protein interaction (PPI) and update of PPI view
- Updates of subdatabases; G-integra, DiseaseInfo Viewer, H-ANGEL, Gene family/groups

README

31-Mar-10  Erratum for H-InvDB_7.0 annotation
In H-InvDB_7.0, annotation for 916 IDs were revised since 16-Feb-10.
Link : erratum20100331.txt

16-Feb-10  H-InvDB 7.0 (Annotated Human Gene Database) was released.
The features of this major release include:
- 296,912 human transcripts in 46,499 human gene clusters (loci).
- updates of human genome sequences to NCBI b37.1 (UCSC hg19).
- Release of new main viewer, "Protein vew". sample
- Release of annotation of ORANGUTAN in G-integra
- Tie-up with GlycoProt DataBase (GPDB)
- Relation to experimental resources (NBRC and HGPD)
- updates of subdatabases; DiseaseInfo Viewer, H-ANGEL, Gene family/groups

README

14-Jan-10  Renewal of HEAT
H-InvDB Enrichment Analysis Tool (HEAT) was renewed. We newly included analysis of common sequence motifs in promoter regions based on the JASPAR database in addition to 8 kinds of annotation such as GO and KEGG pathway. Moreover, HEAT became more useful as it accepts more kinds of IDs and the download function was added. Please try the HEAT.

08-Apr-09  H-InvDB Enrichment Analysis Tool (HEAT), a new tool for GSEA, was released.
H-InvDB Enrichment Analysis Tool (HEAT) is a data-mining tool for automatically identifying features specific to a given human gene set. HEAT searches for H-InvDB annotations that are significantly enriched in a user-defined gene set, as compared with the entire H-InvDB representative transcripts. The following features of H-InvDB are analyzed: InterPro, Gene Ontology (GO), KEGG pathway, Chromosomal band, Gene family, SCOP (structural domains), Subcellular localization prediction (by using Wolf PSORT) and Tissue-specific gene expression (10 tissue categories defined in H-ANGEL). This technique is called Gene Set Enrichment Analysis (GSEA), and is popularly used in analyzing results of microarray experiments.
URL: http://hinv.jp/HEAT/

30-Mar-09  H-InvDB 6.2 (Annotated Human Gene Database) was released.
The features of this minor release include:
- 219,765 human transcripts in 43,161 human gene clusters (loci).
- "Topic annotation for NEDO FL-cDNA Annotation PJ" page newly open.
- G-integra "Comparative mapping track" newly open.
- Evola "Cross-species mapping (CSM) view" newly open.
- tie-up with GlycoGene DataBase (GGDB)
- Annotation data for the molecular evolution (Evola), disease relation (DiseaseInfo Viewer), gene expression (H-ANGEL) and polymorphism were released.
- updates of IDs of the external databases (HUGO, EntrezGene).
- "Statistics"page newly open.

README

04-Feb-09  Erratum for H-InvDB_6.0 annotation
In H-InvDB_6.0, annotation for 194 IDs were revised since 18-Dec-08.
Link : erratum20090204.txt

18-Dec-08  H-InvDB 6.0 (Annotated Human Gene Database) was released.
The features of this major release include:
- updates of human genome sequences to NCBI B36.2.
- 219,765 human transcripts in 43,161 human gene clusters (loci).
- "Topic annotation" page newly open.
- tie-up with the functional RNA database (fRNAdb)
- extended web service (REST and SOAP)
- RSS service started
- Japanese official site opened

README

04-Dec-08  Presentations related to H-InvDB at BMB2008
The 31st Annual Meeting of the Molecular Biology Society of JAPAN, The 81st Annual Meeting of the Japanese Biochemical Society (BMB2007)
9th- 12th December, 2008 at Kobe Port Island, Hyogo, Japan
http://www.aeplan.co.jp/bmb2008/en/


30-Oct-08  Release of a new portal site (medals.jp)
Opened a new portal site that provides various information on databases and analysis tools for life science which were developed by the projects directly sponsored by METI, or developed by the Institutes sponsored by METI.
The name of the site, "MEDALS", stands for METI Database portal for Life Science.
http://medals.jp


22-Oct-08  BIRC server will temporarily stop
The H-InvDB at the BIRC site will be unavailable due to electrical maintenance during the following period.
Please use the DDBJ mirror site (http://hinvdb.ddbj.nig.ac.jp/).
November 28 (Friday) 16:00 - November 29 (Saturday) 24:00 JST.

22-Oct-08  DDBJ server will temporarily stop
The H-InvDB at the DDBJ site will be unavailable due to electrical maintenance during the following period.
Please use the BIRC site (http://h-invitational.jp/hinv/ahg-db/).
October 30 (Friday) 17:00 - November 4 (Tuesday) 12:00 JST.

30-Sep-08  H-InvDB 5.3 (Annotated Human Gene Database) was released.
The features of this minor release include:
- updates of evolutionary annotation at Transcript view, G-integra and Evola.
__ URL : http://h-invitational.jp/evola/
- updates of search index for the copy number variation (CNV).
- updates of IDs of the external databases (HUGO, EntrezGene, InterPro, GO).
- release of Gbrowse of VarySysDB.
__ URL : http://h-invitational.jp/varygene/

30-Sep-08  H-InvDB demo at BioJapan2008.
BioJapan2008, World Bisiness Forum
15-17 October 2008, Pacifico Yokohama, Yokohama, Japan
http://expo.nikkeibp.co.jp/biojapan/eng/index.html


30-Apr-08  BIRC server will temporarily stop
The H-InvDB at the BIRC site will be unavailable due to system maintenance during the following period. August 19 (Tuesdat) 04:30 - 06:30 JST. (1h) Please use the DDBJ mirror site (http://hinvdb.ddbj.nig.ac.jp/).

30-Apr-08  Erratum for H-InvDB_5.0 Evola annotation
In H-InvDB_5.0 Evola, annotation for 1,149 IDs below will be revised in the comming release.
list of IDs

28-Mar-08  New URL of H-InvDB
The URL of H-InvDB was changed since 7 March, 2008 as below;
-current URL
http://jbirc.jbic.or.jp/hinv/
-new URL
http://h-invitational.jp/hinv/

Please update your bookmarks and links !

30-Jan-08  Erratum for H-InvDB_5.0 annotation
In H-InvDB_5.0, annotation for 35,120 IDs were revised since 2007-Dec-26.
Link : erratum20080130.txt

30-Jan-08  New Advanced Search (pre!) was released.
"new Advanced Search (pre!)" was released. The new search system can be accessed from Navi.

26-Dec-07  H-InvDB 5.0 (Annotated Human Gene Database) was released.
The features of this major release include:
- updates of human genome sequences to NCBI B36.2.
- Total amounts of 187,156 human transcripts in 36,073 human gene clusters (loci), with 124,280 proteins annotations(HIPs)
- New IDs of H-Invitational gene family/group IDs (HIF ID)
- predicted genes (eHIT, pHIT)
- Extended annotations for:
    * Gene family/Group
    * protein-protein interactions (PPI)
    * functional RNA
    * sequence quality
- Web service (REST protocol)
- the additional species data in G-integra and Evola (14 species including 2 species added).

22-Nov-07  JBIRC server will temporarily stop
The H-InvDB at the JBIRC site will be unavailable due to electrical maintenance during the following period. Please use the DDBJ mirror site (http://hinvdb.ddbj.nig.ac.jp/).
November 30 (Friday) 16:00 - December 1 (Saturday) 24:00 JST.

27-Sep-07  H-InvDB 4.6 (Annotated Human Gene Database) was released.
The features of this minor release include:
- Microarray probes of DNA Chip Research AceGene, Affymetrix GeneChip, and Agilent.
(from DNAProbeLocator: http://www.jbirc.jbic.or.jp/DNAProbeLocator/ )
- H-InvDB glossary (Both English and Japanese).
http://jbirc.jbic.or.jp/hinv/help/help_Glossary.html
- revisions at SNP annotation.
- updates of RASV (Representative Alternative Splicing Variant) functional annotation.
- updates of IDs of the external databases (HUGO, EntrezGene).

1-Aug-07  Erratum for polymorphism annotation
In H-InvDB_4.3, polymorphism annotation for 20,263 transcriptsare incorrect since 27-Jun-2007.
Link : erratum20070801.txt
VaryGene : http://www.jbirc.jbic.or.jp/varygene/

27-Jun-07  H-InvDB 4.3 (Annotated Human Gene Database) was released.
The features of this minor release include:
- updates of (ncRNA, SNP) annotation.
- modification of annotations about mitochondrial genes.
- updates of IDs of the external databases (HUGO, EntrezGene, InterPro, GO).
- the Japanese page of gene family annotation.
__ URL : http://h-invitational.jp/hinv/genefamily/index_en.cgi
- updates of Evola (Evolutionary annotation database).
__ URL : http://jbirc.jbic.or.jp/hinv/evola/
- release of VaryGene, new database for polymorphism information.
__ URL : http://www.jbirc.jbic.or.jp/varygene/

8-Jun-07  Approval of Evola at the HUMOT project
- Human and Mouse Orthologous Gene Nomenclature project -
http://www.genenames.org/activities/humot/index.html

The HUMOT (Human and Mouse Orthologous Gene Nomenclature) project aims to approve the equivalent gene symbol for each human/mouse ortholog pair, supported by HGNC and MGI.
Evola, a database of evolutionary annotation in H-InvDB,
http://jbirc.jbic.or.jp/hinv/evola/
is now approved as one of the resources of the human/mouse ortholog annotation at the HUMOT project.

11-May-07  The poster presentations of H-InvDB will be presented at HGM2007.
HUGO's 12th Human Genome Meeting (HGM2007)
21-24 May 2007, Montreal Convention Center, Montreal Canada.
http://hgm2007.hugo-international.org/

"Extended annotation for the integrated database of human transcriptome, H-InvDB" Yamasaki C. et al.
"H-DBAS: Alternative Splicing Database of Completely Sequenced and Manually Annotated Full-length cDNAs Based on H-Invitational" Takeda J. et al.

25-Apr-07  The network maintenance at JBIRC server
The H-InvDB at JBIRC site is temporalily unavailable, due to a network maintenance.
April 26 (Thursday) 02:00 - April 26 (Thursday) 04:00 JST.

30-Mar-07  H-InvDB 4.0 (Annotated Human Gene Database) was released on March 30, 2007.
The features of this major release include:
- updates of human genome sequences to NCBI B36.1.
- the new dataset of 175,542 human transcripts in 34,701 human gene clusters (loci).
- annotation of the four selected gene families (TCR, Ig, MHC, Olfactory receptors)
- predicted genes from genome sequences (G-integra)
- Advanced/Navi search
- Transcript view/Locus view
- the additional species data in G-integra and Evola (12 species including 8 species added).

24-Jan-07  The mirror site (DDBJ) will temporarily stop
The H-InvDB mirror at the DDBJ will be unavailable due to maintenance during the following period.
January 26 (Friday) 17:00 - January 28 (Sunday) 13:00 JST.
Services unavailable are:
* mirror site
http://hinvdb.ddbj.nig.ac.jp/ahg-db/index.jsp
* H-Invitational Database CIB-DDBJ Flat File server
http://hinv.ddbj.nig.ac.jp/ (English)
http://hinv.ddbj.nig.ac.jp/index-j.html (Japanese)

20-Dec-06  H-InvDB 3.8 (Annotated Human Gene Database) was released on December 20, 2006.
The features of this minor release include:
- PPI view (protein-protein interaction data).
- updates of IDs of the external databases (HUGO/Entrez Gene).
- updates of?iSNP, ncRNA, AS).
- the Japanese pages of BLAST server and help desk.
- H-DBAS (Alternative Splicing database).

5-Dec-06  The mirror site (DDBJ) will temporarily stop
The H-InvDB mirror at the DDBJ will be unavailable due to maintenance during the following period.
December 9 (Saturday) 8:00 - December 9 (Saturday) 18:00 JST.
Services unavailable are:
* mirror site
http://hinvdb.ddbj.nig.ac.jp/ahg-db/index.jsp
* H-Invitational Database CIB-DDBJ Flat File server
http://hinv.ddbj.nig.ac.jp/ (English)
http://hinv.ddbj.nig.ac.jp/index-j.html (Japanese)

30-Nov-06  The poster presentations/demonstration of H-InvDB in MBSJ2006 Forum
There will be some poster presentations/demonstration of H-InvDB in MBSJ2006 Forum (Nagoya Congress Center), Nagoya, Japan. [December 6 th (Wednesday) - 8 th (Friday), 2006]
See details.
http://jbirc.jbic.or.jp/hinv/ahg-db/presentation.jsp
MBSJ 2006 Forum
http://www.aeplan.co.jp/mbsj2006forum/

6-Nov-06  JBIC server will temporarily stop
The H-InvDB at the JBIC site will be unavailable due to electrical maintenance during the following period. Please use the DDBJ mirror site (http://hinvdb.ddbj.nig.ac.jp/).
November 24 (Friday) 15:00 - November 25 (Saturday) 24:00 JST.

6-Nov-06  The mirror site (DDBJ) will temporarily stop
The H-InvDB mirror at the DDBJ (see below in detail) will be unavailable due to maintenance during the following period.
November 10 (Friday) 17:00 - November 13 (Monday) 10:00 JST.
Services unavailable are:
* mirror site
http://hinvdb.ddbj.nig.ac.jp/ahg-db/index.jsp
* H-Invitational Database CIB-DDBJ Flat File server
http://hinv.ddbj.nig.ac.jp/ (English)
http://hinv.ddbj.nig.ac.jp/index-j.html (Japanese)

28-Sep-06  H-InvDB 3.6 (Annotated Human Gene Database) was released on September 28, 2006.
The features of this minor release include:
- updates of IDs of the external databases (HUGO/Entrez Gene).
- updates of Evola (Evolutionary annotation database).
- the Japanese page of the site map, download site.
- H-InvDB mail magazine.
- subscription and registration page for the mail magazine.

1-Aug-06  H-InvDB mail magazine founded.
H-InvDB mail magazine first released on August 1, 2006.
To subscribe or see back numers, check http://jbirc.jbic.or.jp/hinv/mag/ .

1-Jul-06  Release of new tool: TACT; Transcriptome Auto-annotation Conducting Tool
We developed and released a new web-tool, TACT (TranscriptomeAuto-annotation Conducting Tool ). TACT conduct functional annotation of transcripts by the integration of sequence similarity searches and functional motif predictions. [Nucl. Acids Res. 2006 34]
http://www.jbirc.jbic.or.jp/tact/

23-Jun-06  H-InvDB 3.4 (Annotated Human Gene Database) was released on June 23, 2006.
The features of this minor release include:
- updates of non-protein-coding RNA annotation.
- updates of transcribed pseudogene annotation.
- updates of IDs of the external databases (HUGO/Entrez Gene).
- the Japansese version of help pages.

31-Mar-06  H-InvDB 3.0 (Annotated Human Gene Database) was released on March 31, 2006.
The features of this major release include:
- expansion of the dataset to 167,992 human transcripts in 35,005 human gene clusters (loci).
- updates of all the annotation based on data fixed on March 1, 2005.
- updates of human genome to NCBI B35.1.
- search navigation (wizard).
- site map
- renewal of top/help pages (The top pages have the Japanese language version)
(Note: To change the language configuration, See [ help ])

31-Mar-06  The poster presentations of H-InvDB will be presented at HGM2006.
HUGO's 11th Human Genome Meeting, HGM2006.
[May 31 (Wednesday) to June 3 (Saturday), 2006 at Helsinki, Finland]
http://hgm2006.hugo-international.org/
"Recent Advancement of H-Invitational Database, An Integrated Database of the Human Transcriptome"
Tadashi Imanishi*, Chisato Yamasaki, Katsuhiko Murakami, Yasuyuki Fujii, Yoshiharu Sato, Motohiko Tanino, Ryuichi Sakate, Takayuki Taniya, Yumi Yamaguchi-Kabata and Takashi Gojobori
"TACT: Transcriptome Auto-annotation Conducting Tool of H-InvDB"
Chisato Yamasaki*, Hiroaki Kawashima, Fusano Todokoro, Yasuhiro Imamizu, Makoto Ogawa, Motohiko Tanino, Takeshi Itoh, Takashi Gojobori and Tadashi Imanishi

27-Jan-06  H-InvDB 2.4 was released on January 27, 2006.
The new features include:
- updates of IDs of the external databases (HUGO/Entrez Gene).
- alternative splicing isoforms (pattern classification).

11-Jan-06  Mirror site stop
The H-InvDB mirror at the DDBJ site will not be available due to temporary work during the following period.
January 13 (Friday) 9:00 - January 13 (Friday) 13:00 (JST).

30-Nov-05  H-InvDB was updated on November 30, 2005.
The new features include:
- updates of IDs of the external databases (HUGO/Entrez Gene).
- updates of annotations of SNPs
- a table with the contents of the gene expression profile database (H-ANGEL) is added in the download page.

21-Nov-05  Mirror site stop
The H-InvDB mirror at the DDBJ site will not be available due to electrical maintenance during the following period.
December 2 (Friday) 17:00 - December 3 (Saturday) 22:00.